Veljkovic, V., Mouscadet, J-F., Veljkovic, N., Glisic, S., and Debyser, Z. Against Activity of Reverse Transcriptase HIV Enzyme In Vitro. Effect of Ethanolic Extract of Justicia gendarussa Burm f. Isolation of Male Antifertility Compound in n-Butanol Fraction of Justicia gendarussa Burm.f. Prajogo, B., Guliet, D., Queiroz, F, Wolfernder, J-L., Cholies, N., Aucky, H., and Hostettmann, K. Surabaya: Airlangga University Press dengan LP3 UNAIR. Sebagai Bahan Baku Obat Kontrasepsi Pria. Autentik Tanaman Justicia gendarussa Burm. Oxford Handbook of Genitourinary Medicine, HIV, and Aids, 1st Edition. Virtual high-throughput in silico screening.

Seifert, Kristina Wolf, and Daniel Vitt, 2003. Flavonoids as Potential Inhiibitors of Retroviral Enzymes. Justodrusamides A-D, new 2-aminobenzyl Alcohol Derivatives from Justicia gendarussa. Kiren, Y., Deguchi, J., Hirasawa, Y., Morita, H., and Prajogo, B. Prediction of Drug Absorption Using Multivariate Statistics. Simple Aromatic Amines from Justicia gendarussa 13C NMR Spectra of the Bases and Their Analogues. gendarussa has potential as an anti-HIV.Ĭhakravarty, AK., Dastiar, PPG., and Pakrashi, SC. gendarussa leaves could inhibit the activity of HIV protease enzyme. Gendarusin compounds had good oral bioavailability and were not toxic, and from molecular docking test, it was found that gendarusin of J. The activity prediction was reflected by hydrogen bond and steric bond visible in MVD program with amino acid residue of the receptor of HIV-1 protease. This study used in silico testing methods with FAF-Drugs4 to predict the ADMET (absorption, distribution, metabolism, and excretion–toxicity), and Molegro Virtual Docker (MVD) to predict the activity of five gendarusin compounds to the receptor of HIV-1 protease (PDB ID: 4HLA).

It is expected that this research will provide scientific information on the development of J. gendarussa leaves against HIV-1 protease receptor. This study was conducted to determine the interaction of flavonoids (gendarusin A, B, C, D, and E) on the J. (Acanthaceae) has been known to have anti-HIV activity.

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